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Kang Sun Lee

  • SMALL Member: Jan. 2008 - Sep. 2011

Current Position

  • Research Staff (Oct. 2011 - present)

    • LG Electronics Advanced Institute of Technology, Korea

  • E-mail: kslee1230@gmail.com

  • Web-site: www.SMALL.buffalo.edu/people/kangsun_lee.html
Objective

  • Pursuing a challenging career in research and development of Bio-MEMS, NEMS and Microsystem
Education - Ph.D. (January 2008 – Aug. 2011)

  • University at Buffalo, The State University of New York (SUNY at Buffalo)

  • Department of Electrical Engineering

  • Dissertation: Pressure-driven microfluidic networks using electric circuit analogy for on-chip cell assay application

  • Advisor: Prof. Kwang W. Oh
Education - M.S. (March 2004 – February 2006)

  • Dankook University, Seoul, KOREA

  • Electrical Engineering

  • Thesis topic: Fabrication of LOC system for cell manipulation with a micro fluid mixer and a cell separator

  • Advisors: Prof. Seung-Ki Lee (Dankook University) and Dr. Ji Yoon Kang (KIST)
Education - B.S. ( – February 2004)

  • Dankook University, Seoul, KOREA

  • Electronic and Computer Engineering

  • Related Courses

    • MEMS, Bio-MEMS, Optical electronics, Semiconductor Technology, Electronic circuits Thin film technology, Signal process, System Control, Essential biology, Molecular cell biology, Microfluidics

Research Experience

  • Graduate Research Assistant (2008.1~ Present), Sensor and MicroActuator Learning Laboratory (SMALL), Department of Electrical Engineering, University at Buffalo, The State University of New York

    • Study on microfluidic network-based functional devices: Worked for idea initiation, design, simulation, fabrication, and characterization of the devices as a main researcher

      • Serial dilution device / Hybrid dilution device

      • Combinatorial dilution device for DOE (design of experiment)

      • Hydrodynamic based particle sorter

    • Microfluidic cell culture platform for drug screening: Worked for idea initiation, design, simulation, fabrication, and characterization of the devices as a main researcher

      • Gravity-oriented microfluidic device for 3D cell spheroid formation

      • High-throughput screening (HTS) platform for 2D/3D cell spheroid characterization

    • Microfluidic based SERS (Surface Enhanced Raman Scattering): Worked for idea initiation, design, simulation, fabrication, and characterization of the devices as a main researcher

      • Co-work with Hanyang University (Prof. Choo, Jaebum)

      • SUNY at Buffalo: Microfluidic part

      • Hanyang University: Sensor part

  • Research Scientist (2006.3 ~ 2007.12), Nano-Bio System Laboratory, Microsystem Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea

    • Multi-cell sorter using hydrogel capsules (alginate) with regulated magnetic beads: Worked for idea initiation, design, fabrication, and characterization of the devices as a main researcher

    • Serial dilution device using microfluidic networks: Worked for microfluidic network analysis part

    • Hydrogel beads (alginate beads) generation for using 2-phase (oil-water) microfluidic system: Worked for idea initiation and analysis of oil exchange part

  • Graduate Research Assistant (2005.3 ~ 2006.2), Dankook University / Nano-Bio System Laboratory, Microsystem Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea

    • Study on a novel method to make 3D structure using surface tension of PDMS (Polydimethylsiloxane): Worked for idea initiation, design, fabrication, and characterization of the devices as a main researcher

    • Droplet-based cell sorter for a commercialization: Portable type of magnetically-activated-cell sorter (MACS portable): Worked for design, fabrication, and characterization of the devices as a main researcher

    • LOC system for cell manipulation with a micro fluid mixer and a cell separator: Worked for idea initiation, design, fabrication, and characterization of the devices as a main researcher

  • Graduate Research Assistant (2004.3 ~ 2005.2), Dankook University / DIANA Laboratory, Microsystem Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea

    • Development of droplet based MACS (Magnetically Activated Cell Separator) system: Worked for design and fabrication of disposable cartridges using hand-in injection molding

    • Development of a method to fabricate a microchannel with a round cross section using surface tension: Worked for idea initiation, design, fabrication, and characterization of the devices as a main researcher

    • SPR (Surface Plasmon Resonance) sensor: Learned for fundamental physics of SPR and worked for the device fabrication as an assistant

  • Internship (2003.8 ~ 2004.2), Micro-Robot Laboratory, Microsystem Research Center, Korea Institute of Science and Technology (KIST), Seoul, Korea

    • Fabrication of a cell manipulator using conducting polymer-based micro actuators and dielectrophoresis electrode: Learned for basic micro-fabrication processes and fundamental physics of microactuators
      ��
Skills

  • Fabrication and metrology equipment: MA6 mask aligners, Spinners, RIE, E-beam evaporator, Sputter, ��-Step, Plasma bonding machine

  • Programming and engineering packages experienced: MiniTAB, Origin, P-Spice, COMSOL, Auto CAD, Solid works, 3D-MAX
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Membership/ Activities

  • Review service for journal of Microfluidics and Nanofluidics

  • March 1997~February 2004, Member of the soccer club (DACS) in Dankook University
Award/Fellowships

  • MDRF (Mark Diamond Research Fund) Award in 2011 (From University at Buffalo)
    Grant number: Sp-11-12

  • EE Poster contest award from Dept. of Electrical engineering, University at Buffalo in 2011

  • EE Poster contest award from Dept. of Electrical engineering, University at Buffalo in 2009

  • Teaching assistantship in 2010 and 2011 (From University at Buffalo)

  • Research assistantship in 2008 and 2009 from University at Buffalo

  • Research fund granted from Korea government for Post-master training.

  • Scholarship in August 2005 from Dankook Univeristy

  • Research assistantship in 2004 and 2005 from Korea Institute of Science and Technology
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Publications - Journals

  • Byungwook Ahn, Kangsun Lee, Hun Lee, Rajagopal Panchapakesan, and Kwang W. Oh, "Parallel synchronization of two trains of droplets using a railroad-like channel network," Lab Chip, in publication, 2011

  • Byungwook Ahn, Kangsun Lee, Hun Lee, Rajagopal Panchapakesan, Linfeng Xu, Jing Xu, and Kwang W. Oh, " Guiding, distribution, and storage of trains of shape-dependent droplets," Lab chip, in publication, 2011

  • Kangsun Lee, Choong Kim, Youngeun Kim, Byungwook Ahn, Jaehoon Bang, ��JK�� Jungkwun Kim, Rajagopal Panchapakesan, ��YK�� Yong-Kyu Yoon, Ji Yoon Kang and Kwang W. Oh, ��Microfluidic concentration-on-demand combinatorial dilutions,�� Microfluid Nanofluid, Advance Article: DOI : 10.1007/s10404-011-0775-8 (2011)

  • Choong Kim, Kangsun Lee, Jae hoon Bang, Young Eun Kim, Min-Cheol. Kim, Kwang W. Oh, Soo Hyun Lee and Ji Yoon Kang, ��3-dimensional cell culture for on-chip differentiation of Stem Cells in Embryonic Body,�� Lab Chip, 11, 874 – 882 (2011)

  • Choong Kim, Seok Chung, Young Eun Kim, Kangsun Lee, Soo Hyun. Lee, Kwang W. Oh, and Ji Yoon Kang, ��Generation of core-Shell microcapsules with three-dimensional Focusing Device for Efficient Formation of cell spheroid,�� Lab Chip, 11, 246 – 252 (2011)

  • Kangsun Lee, Choong Kim, Geunhui Jung, Tae Song Kim, Ji Yoon Kang, and Kwang W. Oh, ��Microfluidic network-based combinatorial dilution device for high throughput screening and optimization,�� Microfluid Nanofluid, 8, 677 – 685 (2010)

  • Kangsun Lee, Choong Kim, Youngeun Kim, Keunhui Jung, Byungwook Ahn, Ji Yoon Kang, and Kwang W. Oh, ��2-layer based microfluidic concentration generator by hybrid serial and volumetric dilutions,�� Biomedical Microdevices, 12, 297 – 309 (2010)

  • Kangsun Lee, Choong Kim, Byungwook Ahn, Ji Yoon Kang, and Kwang W. Oh, ��Hydrodynamically focused particle filtration using an island structure,�� Biochip Journal, 3, 275 – 280 (2009)

  • Choong Kim, Kang Sun Lee, Young Eun Kim, Kyu-Jung Lee, Soo Hyun Lee, Tae Song Kim and Ji Yoon Kang, ��Rapid exchange of oil-phase in microencapsulation chip to enhance cell viability,�� Lab Chip, 9, 1294 – 1297 (2009)

  • Byungwook Ahn, Kangsun Lee, Romain Louge and Kwang W. Oh, ��Concurrent droplet charging and sorting by electrostatic actuation,�� Biomicrofluidics, 3, 044102(1) – 044102(8) (2009)

  • Kangsun Lee, Choong Kim, Byungwook Ahn, Rajagopal Panchapakesan, Anthony R. Full, Ledum Nordee, Ji Yoon Kang, and Kwang W. Oh, ��Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators,�� Lab Chip, 9, 709 – 717 (2009)

  • Choong Kim, Kangsun Lee, Kyeong-Sik Shin, Kyujung Lee, Tae Song Kim and Ji Yoon Kang, ��A serial dilution microfluidic device using ladder network generating logarithmic or linear concentrations,�� Lab Chip, 8, 473 – 479 (2008)

  • Kangsun Lee, Choong Kim, Jin Woo Lee, Byeong Kwon Ju, Tae Song Kim, Seung-Ki Lee and Ji Yoon Kang, ��Fabrication of round channel using surface tension of PDMS and its application to a 3D serpentine mixer,�� J. Micromech. Microeng., 17, 1533 – 154 (2007)

  • Youngho Kim, Su-Hong, Sang-Ho Lee, Kangsun Lee, Seok Yun, Yuri Kang, Kyeong-Kap Paek, Byeong-Kwon Ju, Byung-Kyu Kim, ��Novel platform for minimizing cell loss on separation process: Droplet-based magnetically activated cell separator,�� Review of Scientific Instruments, 78 (7) 4301 – 4307 (2007)

  • Choong Kim, In Hye Lee, Kangsun Lee, Sung Shin Ryu, Sangho Lee, KyuJung Lee, Jinwoo Lee, Ji Yoon Kang, and Tae Song Kim, ��Rapid and uniform formation of embryoid body of mouse ES cells in EBAC (embryonic body array chip),�� Bioscience, Biotechnology, and Biochemistry, 71 (12) 2985 – 2991 (2007)

  • Kangsun Lee, Choong Kim, Sung Shin Ryu, In Hye Lee, Byeong Kwon Ju, Seung-Ki Lee and Ji Yoon Kang, ��Droplet based immunomagnetic cell separator,�� Biochip journal, 1 (3), 165 – 172 (2007)
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Publications - Conferences/Workshops

  • Kangsun Lee, Choong Kim, Jaehoon Bang, Youngeun Kim, Seungha Lee, Byungwook Ahn, Ji Yoon Kang and Kwang W. Oh, ��Gravity-oriented microfluidic device for cell spheroid formation,�� The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 3 - 7 October, Groningen, Netherlands (2010)

  • Kangsun Lee, Choong Kim, Youngeun Kim, Jaehoon Bang, Byungwook Ahn, ��JK�� Jungkwun Kim, ��YK�� Yong-Kyu Yoon, Ji Yoon Kang and Kwang W. Oh, ��Microfluidic network-based combinatorial dilution device with an initial concentration controller,�� The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 3 - 7 October, Groningen, Netherlands (2010)

  • Byungwook Ahn, Kangsun Lee, Rajagopal Panchapakesan, Preethi Gopalan, and Kwang W. Oh, ��Robust on-demand electrostatic droplet charging and sorting in a droplet-based microfluidic device,�� The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 3 - 7 October, Groningen, Netherlands (2010)

  • 'JK' Kim, Kangsun Lee, H. Jee, Kwang W. Oh, and Y.-K. Yoon, ��Fabrication of multiple height microstructures using UV lithography on timed-development-and-thermal-reflowed photoresist,�� MEMS Conference, 24-28 January, Hong Kong, 376 – 379 (2010)

  • Kangsun Lee, Byungwook Ahn, and Kwang W. Oh, ��Hydrodynamic focusing based particle filtration using an island structure with built-in valves,�� ASME-IMECE, IMECE2009-11312 (2009)

  • Kangsun Lee, C. Kim, Y. Kim, K. Jung, Byungwook Ahn, J. Y. Kang and Kwang W. Oh, ��2-layer based microfluidic dilution generator for drug screening,�� The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 1 - 5 November, Jeju, Korea, 1264 – 1266 (2009)

  • Kangsun Lee, C. Kim, K. Jung, J. Y. Kang and Kwang W. Oh, ��Microfluidic network based combinatorial device for high throughput screening and optimization,�� The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 1 - 5 November, Jeju, Korea, 1394 - 1396 (2009)

  • J. Kim, Kangsun Lee, Kwang W. Oh, and Y.-K. Yoon, ��Microfabrication of rounded channel and waveguide integrated microlens using timed development and thermal reflow process,�� The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), 1 - 5 November, Jeju, Korea, 1365 – 1367 (2009)

  • Kangsun Lee, Choong Kim, Byungwook Ahn, Yongeun Kim, Ji Yoon Kang, and Kwang W. Oh, ��Microfluidic network based micro-reactor platforms for biological assay,�� Nanotechnology in biology and Medicine, the 2nd Integrated Nanostructured Systems (INS) Workshop, Center for the Arts, The University at Buffalo (SUNY), Buffalo, NY, US, May 13, (2009)

  • Byungwook Ahn, Rajagopal Panchapakesan, Kangsun Lee, Kwang W. Oh, ��Two phase droplet; generation, sorting and droplet charge with E-field,�� Nanotechnology in biology and Medicine, the 2nd Integrated Nanostructured Systems (INS) Workshop, Center for the Arts, The University at Buffalo (SUNY), Buffalo, NY, US, May 13, (2009)

  • Kangsun Lee, Choong Kim, Ji Yoon Kang and Kwang W. Oh, ��Double layer based micro fluidic dilution generator for drug screening,�� Proc. in MMB 2009, the Fifth International Conference on Microtechnologies in Medicine and Biology, Québec City, Canada, April 1-3, 92 - 93 (2009)

  • Byungwook Ahn, Rajagopal Panchapakesan, Kangsun Lee, Romain Louge and Kwang W. Oh, ��Fast, Robust and Simultaneous Sorting with Droplet Generation by Synchronized High Switching Frequency of Electrostatic Actuation,�� The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS), October 12-16, 2008, San Diego, CA (2008)

  • Byungwook Ahn, Rajogopal Panchapakesan, Kangsun Lee and Kwang W. Oh, ��Simultaneous sorting with water droplet formation using an electric field,�� ASME-IMECE Microfluidics 2008, IMECE2008-67920 (2008).

  • Kangsun Lee, Choong Kim, Jung-Rak Lee, Tae Song Kim and Ji Yoon Kang, ��Fabrication and Characterization of Magnetic Alginate Bead Carriers for Multiple Sorting of Cells or Multiplexed Immunoassay��, The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Micro TAS 2007), Paris, France, October 7-11 (2007)

  • Choong Kim, Kangsun Lee, Kyungsik Shin, Jong-Hyun Kim, Kyu-Jung Lee, Ji Yoon Kang and Tae Song Kim, ��Serial dilution chips for arbitrary concentration profile and application for cytotoxycity test��, The 11th International Conference on
    Miniaturized Systems for Chemistry and Life Sciences (Micro TAS 2007), Paris, France, October 7-11 (2007)

  • Choong Kim, Kangsun Lee, In-Hye Lee, Kyungsik Shin, Edward Kang, Kyu-Jung Lee and Ji Yoon Kang ��Three dimensional perfusion culture of encapsulated embryonic stem cells in microfluidic chip��, The 14th international Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 07), Lyon, France, June 10-14 (2007)

  • Choong Kim, Kang Sun Lee, Sung Shin Ryu, Kyung Sik Shin, Kyu Jung Lee, Ji Yoon Kang and Tae Song Kim, ��The serial dilution chip for cytotoxycity and cell differenciation test II��, The 20th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2007), Kobe, Japan, January 21-25 (2007)

  • Choong Kim, Kang Sun Lee, Sung Shin Ryu, Kyung Sik Shin, Kyu Jung Lee, Ji Yoon Kang and Tae Song Kim, ��The serial dilution chip for cytotoxycity and cell differenciation test��, Micro Total Analysis System 2006, Tokyo, Japan, November 5-9 (2006)

  • Kang Sun Lee, Choong Kim, Youngho Kim, Jinwoo Lee, Myung-Hwan Oh, Byeongkwon Ju, and Seung-Ki Lee, ��Fabrication method of Rounded-shaped cross sectional channel using a difference between adsorption and cohesion of PDMS��, The 13th international Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 05), Seoul, Korea, July 5-9 (2005)

  • Kangsun Lee, Choong Kim, Jung-Rak Lee, Jong-Hyun Kim, Tae Song Kim and Ji Yoon Kang, ��Fabrication and characterization of magnetic bead capsules for multiple cell sorting��, The 9th Korean MEMS conference, Jeju, Korea, April 6-7 (2007)

  • Choong Kim, Kangsun Lee, Jong-Hyun Kim, Kyu-Jung Lee, Tae song Kim and Ji Yoon Kang, ��Microencapsulation and embryonic body formation of embryonic stem cells using two-phase microfluidic chip��, The 9th Korean MEMS conference 2007, Jeju, Korea, April 6-7 (2007)

  • Kangsun Lee, Choong Kim, Sung Shin Ryu, Ji Yoon Kang, Byung Kwon Ju and Seung-Ki Lee, ��Fabrication of a micro mixer using surface tension and the application for a cell separator��, The 8th Korean MEMS conference 2006, Jeju, Korea, April 5-6 (2006)

  • Kang Sun Lee, Choong Kim, Jin Woo Lee, Ji Yoon Kang, Myung Hwan Oh, Byung Kwon Ju, Seung-Ki Lee, ��Characterization of rounded cross-section microchannels fabricated by using of surface tension��, International Sensors Conference, Taejon, November 11-12 (2005)

  • Kang Sun Lee, Youngho Kim, Seok Yoon, Yu Ri Kang, Dae Seok Na, Jin Woo Lee, Kyung Kwap Beak, Myung Hwan Oh,Byung Kwon Ju and Seung-Ki Lee, ��Fabrication method of round-shaped microchannel using surface tension of PDMS��, The International Sensors Conference, Jeju, November (2004)

  • Jung-ryul Park, Seok Yun, Kang Sun Lee, Byunkyu Kim, Byunkwon Ju and Kyo-Il Lee, ��Design and analysis of Dielectrophoretically Activated Cell Sorting system using 3D-Asymmetric Microelectrodes��, The 6th Korean MEMS Conference, Jeju, April 8-10 (2004)
Patents

  • Kangsun Lee, Sung Shin Ryu In Hye Lee, Choong Kim and Ji Yoon Kang, �� Apparatus and method for separating biological particles using difference between gravity and magnetic force��, PCT/KR2007/197 (2007)

  • Ji Yoon Kang, Choong Kim, Kangsun Lee, Sung-Shin Ryu, Tae Song Kim ��A chip having microchannels and a method for continuous dilution of solution��, Korea, 2007-0035440 (2007)

  • Kang Sun Lee, Sung Shin Ryu, In Hye Lee, Choong Kim, Su Kyung Chae, Jin Woo Lee and Ji Yoon Kang, ��Apparatus and method for separating biological particles using difference between gravity and magnetic force��, Korea, 2006-0003260 (2006)

  • Choong Kim, Su Kyung Chae, Kang Sun Lee, In Hye Lee, Jin Woo Lee, Ji Yoon Kang and Tae Song Kim, ��Method and apparatus for forming and growing embryonic body��, Korea, 2006-0003249 (2006)

  • Kang Sun Lee, Choong Kim, Su Kyung Chae, Jin Woo Lee, Tae Song Kim, Ji Yoon Kang, Byung Kwon Ju, Seung-Ki Lee, ��A method of fabricating microchannel using surface tension and the microchannel��, Korea, 2005-32696 (2005)

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